Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

Excess generation of reactive oxygen species (ROS) and cytosolic calcium accumulation
play major roles in the initiation of programmed cell death during acute myocardial …

In addition to their normal physiological role in ATP production and metabolism,
mitochondria exhibit a dark side mediated by the opening of a non-specific pore in the inner …

Numerous studies propose that epigallocatechin-3-gallate (EGCG), an abundant polyphenol
in green tea, has anti-cancer properties. However, its mechanism of action in breast cancer …

Global increases in small ubiquitin‐like modifier (SUMO)‐2/3 conjugation are a
neuroprotective response to severe stress but the mechanisms and specific target proteins …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline and memory loss. Despite advances in understanding the …

Age‐related macular degeneration (AMD) affects the retinal macula and results in loss of
vision, and AMD is the primary cause of blindness and severe visual impairment among …

The role of ceramide neo-genesis in cellular stress response signaling is gaining increasing
attention with recent progress in elucidating the novel roles and biochemical properties of …