Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of
what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular …
what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular …
Oocyte–somatic cell interactions during follicle development in mammals
Our current perspectives on the relationship between the oocyte and its surrounding somatic
cells are changing as we gain a greater understanding of factors regulating folliculogenesis …
cells are changing as we gain a greater understanding of factors regulating folliculogenesis …
Molecular aspects and clinical relevance of GDF9 and BMP15 in ovarian function
Growth and differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are
oocyte-secreted factors with a leading role in the control of ovarian function in female …
oocyte-secreted factors with a leading role in the control of ovarian function in female …
Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation
Oocytes regulate follicle growth by secreting paracrine growth factors that act on
neighbouring granulosa cells (GCs). Those factors identified to date are mainly members of …
neighbouring granulosa cells (GCs). Those factors identified to date are mainly members of …
Oocyte-secreted factor (s) determine functional differences between bovine mural granulosa cells and cumulus cells
R Li, RJ Norman, DT Armstrong… - Biology of …, 2000 - academic.oup.com
Cumulus cells and mural granulosa cells (MGC) are phenotypically different and there is
now evidence suggesting that the oocyte plays an active role in determining the fate of …
now evidence suggesting that the oocyte plays an active role in determining the fate of …
Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad
Ovarian follicles undergo exponential growth in response to follicle-stimulating hormone
(FSH), largely as a result of the proliferation of granulosa cells (GCs). In vitro under serum …
(FSH), largely as a result of the proliferation of granulosa cells (GCs). In vitro under serum …
Role of oocyte-secreted growth differentiation factor 9 in the regulation of mouse cumulus expansion
RA Dragovic, LJ Ritter, SJ Schulz, F Amato… - …, 2005 - academic.oup.com
Oocyte-secreted factors are required for expansion of the mouse cumulus-oocyte complex,
which is necessary for ovulation. Oocyte-secreted growth differentiation factor 9 (GDF9) …
which is necessary for ovulation. Oocyte-secreted growth differentiation factor 9 (GDF9) …
Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells
N Kaivo-Oja, J Bondestam… - The Journal of …, 2003 - academic.oup.com
The TGFβ family member growth differentiation factor-9 (GDF-9) is an oocyte-derived factor
that is essential for mammalian ovarian folliculogenesis. GDF-9 mRNAs have been shown to …
that is essential for mammalian ovarian folliculogenesis. GDF-9 mRNAs have been shown to …
Differential regulation of inhibin B and inhibin a by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral follicles
CK Welt, AL Schneyer - The Journal of Clinical Endocrinology & …, 2001 - academic.oup.com
Serum inhibin B rises across the luteal-follicular transition, whereas inhibin A does not
increase until the late follicular phase of the menstrual cycle. To test the hypothesis that …
increase until the late follicular phase of the menstrual cycle. To test the hypothesis that …
[PDF][PDF] Ovarian follicle development in the laying hen is accompanied by divergent changes in inhibin A, inhibin B, activin A and follistatin production in granulosa and …
TM Lovell, RT Gladwell, NP Groome… - Journal of Endocrinology, 2003 - Citeseer
To study the potential involvement of inhibin A (inhA), inhibin B (inhB), activin A (actA) and
follistatin (FS) in the recruitment of follicles into the preovulatory hierarchy, growing follicles …
follistatin (FS) in the recruitment of follicles into the preovulatory hierarchy, growing follicles …