DNA damage and associated DNA repair defects in disease and premature aging
Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …
DNA oxidation and excision repair pathways
The physiological impact of the aberrant oxidation products on genomic DNA were
demonstrated by embryonic lethality or the cancer susceptibility and/or neurological …
demonstrated by embryonic lethality or the cancer susceptibility and/or neurological …
Drugging the cancers addicted to DNA repair
Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from
DNA repair defects were once thought to be limited to rare inherited mutations (such as …
DNA repair defects were once thought to be limited to rare inherited mutations (such as …
The current state of eukaryotic DNA base damage and repair
DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
Comprehensive toxicological assessment of halobenzoquinones in drinking water at environmentally relevant concentration
Y Wang, F Wang, L Li, L Zhang, M Song… - … Science & Technology, 2024 - ACS Publications
Halobenzoquinones (HBQs), an emerging unregulated category of disinfection byproduct
(DBP) in drinking water, have aroused an increasing concern over their potential health …
(DBP) in drinking water, have aroused an increasing concern over their potential health …
Reconsidering the chemical nature of Strand breaks derived from abasic sites in cellular DNA: evidence for 3′-glutathionylation
The hydrolytic loss of coding bases from cellular DNA is a common and unavoidable
reaction. The resulting abasic sites can undergo β-elimination of the 3′-phosphoryl group …
reaction. The resulting abasic sites can undergo β-elimination of the 3′-phosphoryl group …
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA
Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove
unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to …
unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to …
A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites
Interstrand DNA–DNA cross-links are highly toxic lesions that are important in medicinal
chemistry, toxicology, and endogenous biology. In current models of replication-dependent …
chemistry, toxicology, and endogenous biology. In current models of replication-dependent …
Selective anti-tumor activity of glutathione-responsive abasic site trap** agent in anaplastic thyroid carcinoma
J Chai, M Su, R Zhang, N Li, Y Jia, W Zheng, J Tan… - BMC cancer, 2024 - Springer
Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid cancer with poor
prognosis. Killing cancer cells by inducing DNA damage or blockage of DNA repair is a …
prognosis. Killing cancer cells by inducing DNA damage or blockage of DNA repair is a …
Key amino acid residues of mitochondrial transcription factor A synergize with abasic (AP) site dynamics to facilitate AP-lyase reactions
Human mitochondrial DNA (mtDNA) encodes 37 essential genes and plays a critical role in
mitochondrial and cellular functions. mtDNA is susceptible to damage by endogenous and …
mitochondrial and cellular functions. mtDNA is susceptible to damage by endogenous and …