Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC …

Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

Objective Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and
lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined …

Intrinsic and evasive antiangiogenic drug (AAD) resistance is frequently developed in
cancer patients, and molecular mechanisms underlying AAD resistance remain largely …

Development of novel and effective therapeutics for treating various cancers is probably the
most congested and challenging enterprise of pharmaceutical companies. Diverse drugs …

The use of nanomedicine for antitumor therapy has been extensively investigated for a long
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …

FGF-2 displays multifarious functions in regulation of angiogenesis and vascular
remodeling. However, effective drugs for treating FGF-2+ tumors are unavailable. Here we …