The intracellular coral–dinoflagellate symbiosis is the engine that underpins the success of
coral reefs, one of the most diverse ecosystems on the planet. However, the breakdown of …

Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

The hypoxic tumor microenvironment (TME) significantly affects cancer treatment.
Conventional chemotherapeutic agents cannot effectively target hypoxic tumor tissue, which …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides
by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive …

Abstract Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the
endoplasmic reticulum, where they impact Ca2+ dynamics by controlling IP3 receptor (IP3R) …

Multiple forms of regulated cell death (RCD) have been characterized, each of which
originates from the activation of a dedicated molecular machinery. RCD can occur in purely …

Endoplasmic reticulum (ER)-mitochondria contact sites are crucial to allow Ca 2+ flux
between them and a plethora of proteins participate in tethering both organelles together …