In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Apoptosis plays a major role in sha** the develo** nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Abstract BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis.
They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as …

Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve.
For several decades, we have understood that the RGC death process was executed by …

NF-κB may be a potential therapeutic target for acute myelogenous leukemia (AML)
because NF-κB activation is found in primitive human AML blast cells. In this report, we …

Stringent transcriptional regulation is crucial for normal cellular biology and organismal
development. Perturbations in the proper regulation of transcription factors can result in …

Apoptosis is a genetically programmed process for the elimination of damaged or redundant
cells by activation of caspases (aspartate-specific cysteine proteases). Caspases cleave …

Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of
advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib …

Cytokines produced by islet-infiltrating immune cells induce β-cell apoptosis in type 1
diabetes. The IFN-γ-regulated transcription factors STAT1/IRF-1 have apparently divergent …