Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

[HTML][HTML] State of the nation in data integration for bioinformatics

C Goble, R Stevens - Journal of biomedical informatics, 2008 - Elsevier
Data integration is a perennial issue in bioinformatics, with many systems being developed
and many technologies offered as a panacea for its resolution. The fact that it is still a …

An introduction to ontology engineering

CM Keet - 2018 - open.uct.ac.za
Abstract An Introduction to Ontology Engineering is a free online textbook that provides an
overview of ontology engineering, including logics and automated reasoning, methods and …

myExperiment: social networking for workflow-using e-scientists

CA Goble, DC De Roure - Proceedings of the 2nd workshop on …, 2007 - dl.acm.org
We present the Taverna workflow workbench and argue that scientific workflow
environments need a rich ecosystem of tools that support the scientists. experimental …

[PDF][PDF] Scientific Process Automation and Workflow Management.

B Ludäscher, I Altintas, S Bowers… - Scientific Data …, 2009 - academia.edu
We introduce and describe scientific workflows, ie, executable descriptions of automatable
scientific processes such as computational science simulations and data analyses. Scientific …

[HTML][HTML] An ontology-driven semantic mashup of gene and biological pathway information: Application to the domain of nicotine dependence

SS Sahoo, O Bodenreider, JL Rutter, KJ Skinner… - Journal of biomedical …, 2008 - Elsevier
OBJECTIVES: This paper illustrates how Semantic Web technologies (especially RDF, OWL,
and SPARQL) can support information integration and make it easy to create semantic …

Scientific discovery as a combinatorial optimisation problem: how best to navigate the landscape of possible experiments?

DB Kell - Bioessays, 2012 - Wiley Online Library
A considerable number of areas of bioscience, including gene and drug discovery,
metabolic engineering for the biotechnological improvement of organisms, and the …

Data curation+ process curation= data integration+ science

C Goble, R Stevens, D Hull… - Briefings in …, 2008 - academic.oup.com
In bioinformatics, we are familiar with the idea of curated data as a prerequisite for data
integration. We neglect, often to our cost, the curation and cataloguing of the processes that …

The virtual human: towards a global systems biology of multiscale, distributed biochemical network models

DB Kell - IUBMB life, 2007 - Wiley Online Library
There is an emerging recognition of the importance of modelling large‐scale biochemical
systems, with the 'digital human'an obviously desirable goal. This will then permit …

Molecular Recognition at an Organic− Aqueous Interface: Heterocalixarenes as Anion Binding Agents in Liquid Polymeric Membrane Ion-Selective Electrodes

V Král, JL Sessler, TV Shishkanova… - Journal of the …, 1999 - ACS Publications
Poly (vinyl chloride)(PVC)-derived ion-selective electrodes (ISEs) have been prepared from
a neutral anion binding receptor, meso-octamethylcalix [4] pyrrole (1). Analogous systems …