Decellularized matrix (dECM) is isolated extracellular matrix of tissues from its original
inhabiting cells, which has emerged as a promising natural biomaterial for tissue …

The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …

The lack of cancer-associated fibroblasts (CAFs) in patient-derived organoid (PDO) models
is a major limitation as CAFs contribute to tumor progression and drug resistance. In the …

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading
cause of cancer worldwide. Despite approvals of several therapeutics to treat advanced …

Ethnopharmacological relevance Chinese medicine formula (CMF) has a long history of
clinical use in the treatment of various diseases under the guidance of traditional Chinese …

With advances in the discovery of the clinical and molecular landscapes of prostate cancer
(PCa), implementation of precision medicine-guided therapeutic testing in the clinic has …

Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …

Evolving understanding of structural and biological complexity of tumors has stimulated
development of physiologically relevant tumor models for cancer research and drug …

Three-dimensional cell cultures, such as spheroids and organoids, serve as increasingly
important models in fundamental and applied research and start to be used for drug …

3D organoid model technologies have led to the development of innovative tools for cancer
precision medicine. Yet, the gold standard culture system (Matrigel®) lacks the ability for …