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Polyamines in cancer: integrating organismal metabolism and antitumour immunity
CE Holbert, MT Cullen, RA Casero Jr… - Nature Reviews …, 2022 - nature.com
The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …
Bifidobacterium mechanisms of immune modulation and tolerance
Bifidobacterium is a widely distributed commensal bacterial genus that displays beneficial
pro-homeostatic and anti-inflammatory immunomodulatory properties. Depletion or absence …
pro-homeostatic and anti-inflammatory immunomodulatory properties. Depletion or absence …
Mechanisms of spermidine-induced autophagy and geroprotection
Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …
recently discovered compounds that extend the healthspan and lifespan of model organisms …
Hallmarks of T cell aging
The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice
M Al-Habsi, K Chamoto, K Matsumoto, N Nomura… - Science, 2022 - science.org
Spermidine (SPD) delays age-related pathologies in various organisms. SPD
supplementation overcame the impaired immunotherapy against tumors in aged mice by …
supplementation overcame the impaired immunotherapy against tumors in aged mice by …
Polyamine metabolism is a central determinant of helper T cell lineage fidelity
Polyamine synthesis represents one of the most profound metabolic changes during T cell
activation, but the biological implications of this are scarcely known. Here, we show that …
activation, but the biological implications of this are scarcely known. Here, we show that …
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
Intestinal microbiota-derived metabolites have biological importance for the host.
Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota …
Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota …
[HTML][HTML] The gut ecosystem and immune tolerance
The gastrointestinal tract is home to the largest microbial population in the human body. The
gut microbiota plays significant roles in the development of the gut immune system and has …
gut microbiota plays significant roles in the development of the gut immune system and has …
Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers
The circulating metabolome provides a snapshot of the physiological state of the organism
responding to pathogenic challenges. Here we report alterations in the plasma metabolome …
responding to pathogenic challenges. Here we report alterations in the plasma metabolome …
Microbial metabolites and gut immunology
The intestine is the largest peripheral lymphoid organ in animals, including humans, and
interacts with a vast array of microorganisms called the gut microbiota. Comprehending the …
interacts with a vast array of microorganisms called the gut microbiota. Comprehending the …