Neutrophils in chronic inflammatory diseases

A Herrero-Cervera, O Soehnlein… - Cellular & molecular …, 2022 - nature.com
Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

The roles of inflammation in keloid and hypertrophic scars

ZC Wang, WY Zhao, Y Cao, YQ Liu, Q Sun… - Frontiers in …, 2020 - frontiersin.org
The underlying mechanisms of wound healing are complex but inflammation is one of the
determining factors. Besides its traditional role in combating against infection upon injury …

Targeting CAFs to overcome anticancer therapeutic resistance

PE Saw, J Chen, E Song - Trends in cancer, 2022 - cell.com
The view of cancer as a tumor cell-centric disease is now replaced by our understanding of
the interconnection and dependency of tumor stroma. Cancer-associated fibroblasts (CAFs) …

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

C Radermecker, N Detrembleur, J Guiot… - Journal of Experimental …, 2020 - rupress.org
Infection with SARS-CoV-2 is causing a deadly and pandemic disease called coronavirus
disease–19 (COVID-19). While SARS-CoV-2–triggered hyperinflammatory tissue-damaging …

Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs)

P Spagnolo, O Distler, CJ Ryerson… - Annals of the …, 2021 - ard.bmj.com
Interstitial lung diseases (ILDs), which can arise from a broad spectrum of distinct
aetiologies, can manifest as a pulmonary complication of an underlying autoimmune and …

Autophagy and inflammation in chronic respiratory disease

AC Racanelli, SA Kikkers, AMK Choi, SM Cloonan - Autophagy, 2018 - Taylor & Francis
Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …

The emerging roles of neutrophil extracellular traps in wound healing

S Zhu, Y Yu, Y Ren, L Xu, H Wang, X Ling, L **… - Cell Death & …, 2021 - nature.com
Delayed wound healing causes problems for many patients both physically and
psychologically, contributing to pain, economic burden, loss of function, and even …

[HTML][HTML] Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

JD Dunn, LAJ Alvarez, X Zhang, T Soldati - Redox biology, 2015 - Elsevier
Reactive oxygen species (ROS) are integral components of multiple cellular pathways even
though excessive or inappropriately localized ROS damage cells. ROS function as anti …

Post-COVID-19 pulmonary fibrosis: novel sequelae of the current pandemic

SR Ambardar, SL Hightower, NA Huprikar… - Journal of clinical …, 2021 - mdpi.com
Since the initial identification of the novel coronavirus SARS-CoV-2 in December 2019, the
COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As …