Cooperative assembly of TGF-β superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
Dimeric ligands of the transforming growth factor-β (TGF-β) superfamily signal across cell
membranes in a distinctive manner by assembling heterotetrameric complexes of …
membranes in a distinctive manner by assembling heterotetrameric complexes of …
Crystal structure of the human TβR2 ectodomain–TGF-β3 complex
Transforming growth factor-β (TGF-β) is the prototype of a large family of structurally related
cytokines that play key roles in maintaining cellular homeostasis by signaling through two …
cytokines that play key roles in maintaining cellular homeostasis by signaling through two …
Ternary complex of transforming growth factor-β1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Transforming growth factor (TGF)-β1,-β2, and-β3 are 25-kDa homodimeric polypeptides that
play crucial nonoverlap** roles in embryogenesis, tissue development, carcinogenesis …
play crucial nonoverlap** roles in embryogenesis, tissue development, carcinogenesis …
TGF‐β signalling is mediated by two autonomously functioning TβRI: TβRII pairs
Transforming growth factor (TGF)‐βs are dimeric polypeptides that have vital roles in
regulating cell growth and differentiation. They signal by assembling a receptor …
regulating cell growth and differentiation. They signal by assembling a receptor …
Biological activity differences between TGF-β1 and TGF-β3 correlate with differences in the rigidity and arrangement of their component monomers
TGF-β1,-β2, and-β3 are small, secreted signaling proteins. They share 71–80% sequence
identity and signal through the same receptors, yet the isoform-specific null mice have …
identity and signal through the same receptors, yet the isoform-specific null mice have …
Three key residues underlie the differential affinity of the TGFβ isoforms for the TGFβ type II receptor
G De Crescenzo, CS Hinck, Z Shu, J Zúñiga… - Journal of molecular …, 2006 - Elsevier
TGFβ1, β2, and β3 are 25kDa homodimeric polypeptides that play crucial non-overlap**
roles in development, tumor suppression, and wound healing. They exhibit 70–82 …
roles in development, tumor suppression, and wound healing. They exhibit 70–82 …
Binding properties of the transforming growth factor-β coreceptor betaglycan: proposed mechanism for potentiation of receptor complex assembly and signaling
MM Villarreal, SK Kim, L Barron, R Kodali… - Biochemistry, 2016 - ACS Publications
Transforming growth factor (TGF) β1, β2, and β3 (TGF-β1–TGF-β3, respectively) are small
secreted signaling proteins that each signal through the TGF-β type I and type II receptors …
secreted signaling proteins that each signal through the TGF-β type I and type II receptors …
Assembly of TβRI: TβRII: TGFβ ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent
JE Zúñiga, JC Groppe, Y Cui, CS Hinck… - Journal of molecular …, 2005 - Elsevier
Transforming growth factor-β (TGFβ) isoforms initiate signaling by assembling a
heterotetrameric complex of paired type I (TβRI) and type II (TβRII) receptors on the cell …
heterotetrameric complex of paired type I (TβRI) and type II (TβRII) receptors on the cell …
An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling
SK Kim, L Barron, CS Hinck, EM Petrunak… - Journal of Biological …, 2017 - ASBMB
The transforming growth factor β isoforms, TGF-β1,-β2, and-β3, are small secreted
homodimeric signaling proteins with essential roles in regulating the adaptive immune …
homodimeric signaling proteins with essential roles in regulating the adaptive immune …
TβR-II discriminates the high-and low-affinity TGF-β isoforms via two hydrogen-bonded ion pairs
The TGF-β isoforms, TGF-β1,-β2, and-β3, share greater than 70% sequence identity and are
almost structurally identical. TGF-β2 differs from the others, however, in that it binds the TGF …
almost structurally identical. TGF-β2 differs from the others, however, in that it binds the TGF …