Altered brain responses to alcohol-associated stimuli are a neural hallmark of alcohol-use
disorder (AUD) and a promising target for pharmacotherapy. However, findings in cue …

Given the strong evidence for neurological alterations at the basis of drug dependence,
functional magnetic resonance imaging (fMRI) represents an important tool in the clinical …

Background Preclinical research has demonstrated a causal relationship between medial
prefrontal cortex activity and cocaine self-administration. As a step towards translating those …

Naltrexone reduces drinking among individuals with alcohol use disorders (AUDs), but it is
not effective for everyone. Variability in its effects on reward-related brain activation, genetic …

Background Alcohol dependence is a major public health problem that is characterised by
recidivism and a host of medical and psychosocial complications. Besides psychosocial …

Background The alcohol cue reactivity paradigm is increasingly used to screen medications
for the treatment of alcohol use disorder (AUD) and other substance use disorders. Yet, its …

Background: Inflammation is implicated in alcohol use disorder (AUD). Ibudilast, a
neuroimmune modulator, shows promise for the treatment of AUD. Elevated inflammation …

In spite of high prevalence and disease burden, scientific consensus on the etiology and
treatment of Alcohol Use Disorder (AUD) has yet to be reached. The development and …

Rationale Baclofen has been shown to effect fMRI alcohol cue reactivity in alcohol
dependence, but potential varying effects related to baclofen dose levels have not been …

Alcohol use disorder (AUD) is a chronic relapsing condition that represents a significant
public health concern. Pharmacological treatment development for AUD is a top research …