Objective: The authors provide an evidenced-based summary of the literature on the clinical
application of psychedelic drugs in psychiatric disorders. Methods: Searches of PubMed and …

Background Depression and anxiety are prevalent psychiatric disorders that carry significant
morbidity. Pharmacological and psychosocial interventions are used to manage these …

Introduction Ayahuasca is a plant-based decoction native to Amazonia, where it has a long
history of use in traditional medicine. Contemporary ritual use of ayahuasca has been …

Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants
and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being …

Acute adverse psychological reactions to classic hallucinogens (“bad trips” or “challenging
experiences”), while usually benign with proper screening, preparation, and support in …

The experiences induced by psychedelics share a wide variety of subjective features,
related to the complex changes in perception and cognition induced by this class of drugs. A …

To date, pharmacological treatments for mood and anxiety disorders and for drug
dependence show limited efficacy, leaving a large number of patients suffering severe and …

Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents
are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central …

Rationale Major depressive disorder is one of the leading global causes of disability, for
which the classic serotonergic psychedelics have recently reemerged as a potential …

Rationale Ayahuasca is a psychotropic plant tea from South America used for religious
purposes by indigenous people of the Amazon. Increasing evidence indicates that …