A guide to plasma membrane solute carrier proteins
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …
of transporter proteins and their roles in human cells. The SLC superfamily currently …
Engaging neuroscience to advance translational research in brain barrier biology
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of
the brain is restricted by brain barriers, of which the most well known are the blood–brain …
the brain is restricted by brain barriers, of which the most well known are the blood–brain …
[HTML][HTML] The cellular mechanisms of neuronal swelling underlying cytotoxic edema
Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality
following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze …
following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze …
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
Role of NKCC1 and KCC2 in epilepsy: from expression to function
R Liu, J Wang, S Liang, G Zhang, X Yang - Frontiers in neurology, 2020 - frontiersin.org
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …
Intracellular pH regulation by acid-base transporters in mammalian neurons
Intracellular pH (pHi) regulation in the brain is important in both physiological and
physiopathological conditions because changes in pHi generally result in altered neuronal …
physiopathological conditions because changes in pHi generally result in altered neuronal …
Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures
Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is
not clinically manifest. Uncoupling increases after treatment with Phenobarbital, which …
not clinically manifest. Uncoupling increases after treatment with Phenobarbital, which …
Chloride dysregulation, seizures, and cerebral edema: a relationship with therapeutic potential
Pharmacoresistant seizures and cytotoxic cerebral edema are serious complications of
ischemic and traumatic brain injury. Intraneuronal Cl− concentration ([Cl−] i) regulation …
ischemic and traumatic brain injury. Intraneuronal Cl− concentration ([Cl−] i) regulation …
Modular structure of sodium-coupled bicarbonate transporters
Mammalian genomes contain 10 SLC4 genes that, between them, encode three Cl–HCO3
exchangers, five Na+-coupled HCO3 transporters (NCBTs), one reported borate transporter …
exchangers, five Na+-coupled HCO3 transporters (NCBTs), one reported borate transporter …
Bicarbonate transport in health and disease
K Alka, JR Casey - IUBMB life, 2014 - Wiley Online Library
Abstract Bicarbonate (HCO3−) has a central place in human physiology as the waste
product of mitochondrial energy production and for its role in pH buffering throughout the …
product of mitochondrial energy production and for its role in pH buffering throughout the …