Latent tuberculosis infection (LTBI) is a subclinical mycobacterial infection defined on the
basis of cellular immune response to mycobacterial antigens. The tuberculin skin test (TST) …

Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy,
Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most …

Identification and treatment of latent tuberculosis infection (LTBI) can substantially reduce
the risk of develo** active disease. However, there is no diagnostic gold standard for LTBI …

Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

In 2005, CDC published guidelines for using the QuantiFERON-TB Gold test (QFT-
G)(Cellestis Limited, Carnegie, Victoria, Australia)(CDC. Guidelines for using the …

Background: Until recently, the tuberculin skin test was the only test for detecting latent
tuberculosis (TB) infection, but 2 ex vivo interferon-γ release assays (IGRAs) are now …

The billions of people with latent tuberculosis infection serve as the seedbeds for future
cases of active tuberculosis. Virtually all episodes of tuberculosis disease are preceded by a …

Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …

The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …

Biomarkers are indispensable to the development of new tuberculosis therapeutics and
vaccines. The most robust biomarkers measure factors that are essential to the underlying …