Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders
M Mohammadi, R Goetz - US Patent 9,475,856, 2016 - Google Patents
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …
Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use
M Mohammadi, R Goetz - US Patent 9,550,820, 2017 - Google Patents
The present invention relates to an isolated chimeric protein. The isolated chimeric protein
includes an N-terminus coupled to a C-terminus, where the N-terminus includes an N …
includes an N-terminus coupled to a C-terminus, where the N-terminus includes an N …
Chimeric fibroblast growth factor 23 proteins and methods of use
M Mohammadi, R Goetz - US Patent 9,657,075, 2017 - Google Patents
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C (NC (= O) C) C
(O) OC (COS (O)(= O)= O) C1OC1C (OS (O)(= O)= O) C (O) C (OC2C (C (OS (O)(= O)= O) C …
(O) OC (COS (O)(= O)= O) C1OC1C (OS (O)(= O)= O) C (O) C (OC2C (C (OS (O)(= O)= O) C …
Compositions comprising variants and fusions of FGF19 polypeptides
L Ling, DA Lindhout - US Patent 9,290,557, 2016 - Google Patents
HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=
C2C [C@@ H](O) CC [C@] 2 (C)[C@@ H] 2 [C@@ H] 1 [C@@ H] 1CC [C@ H]([C@ H](C) …
C2C [C@@ H](O) CC [C@] 2 (C)[C@@ H] 2 [C@@ H] 1 [C@@ H] 1CC [C@ H]([C@ H](C) …
Chimeric fibroblast growth factor 19 proteins and methods of use
M Mohammadi, R Goetz - US Patent 9,474,785, 2016 - Google Patents
US9474785B2 - Chimeric fibroblast growth factor 19 proteins and methods of use - Google
Patents US9474785B2 - Chimeric fibroblast growth factor 19 proteins and methods of use …
Patents US9474785B2 - Chimeric fibroblast growth factor 19 proteins and methods of use …
Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
L Ling, H Tian - US Patent 10,456,449, 2019 - Google Patents
Provided herein are methods of modulating bile acid homeostasis or treating a bile-acid
related or associated disorder, comprising using variants and fusions of fibroblast growth …
related or associated disorder, comprising using variants and fusions of fibroblast growth …
Methods of using compositions comprising variants and fusions of FGF19 polypeptides for treatment of diabetes
L Ling, DA Lindhout - US Patent 9,580,483, 2017 - Google Patents
US9580483B2 - Methods of using compositions comprising variants and fusions of FGF19
polypeptides for treatment of diabetes - Google Patents US9580483B2 - Methods of using …
polypeptides for treatment of diabetes - Google Patents US9580483B2 - Methods of using …
Pharmaceutical compositions comprising FGF19 variants
DA Lindhout, CV Olson - US Patent 10,517,929, 2019 - Google Patents
HDTRYLNUVZCQOY-LIZSDCNHSA-N Trehalose Chemical compound O [C@@ H] 1 [C@@
H](O)[C@ H](O)[C@@ H](CO) O [C@@ H] 1O [C@@ H] 1 [C@ H](O)[C@@ H](O)[C …
H](O)[C@ H](O)[C@@ H](CO) O [C@@ H] 1O [C@@ H] 1 [C@ H](O)[C@@ H](O)[C …
Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
L Ling, J Luo - US Patent 9,273,107, 2016 - Google Patents
Bile acids, steroid acids that are found predominantly in the bile of mammals, regulate
cholesterol, triglyceride, glucose and energy homeostasis, and facilitate digestion and …
cholesterol, triglyceride, glucose and energy homeostasis, and facilitate digestion and …
Compositions comprising fusion variants of FGF19 polypeptides
L Ling, DA Lindhout - US Patent 9,670,260, 2017 - Google Patents
US9670260B2 - Compositions comprising fusion variants of FGF19 polypeptides - Google
Patents US9670260B2 - Compositions comprising fusion variants of FGF19 polypeptides …
Patents US9670260B2 - Compositions comprising fusion variants of FGF19 polypeptides …