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Intrinsically disordered proteins play diverse roles in cell signaling
Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …
The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
Tumor suppressor PTEN, the second most highly mutated protein in cancer,
dephosphorylates signaling lipid PIP 3 produced by PI3Ks. Excess PIP 3 promotes cell …
dephosphorylates signaling lipid PIP 3 produced by PI3Ks. Excess PIP 3 promotes cell …
Combined analysis of PTEN, HER2, and hormone receptors status: remodeling breast cancer risk profiling
Background Phosphatase and tensin homolog (PTEN) loss is associated with
tumorigenesis, tumor progression, and therapy resistance in breast cancer. However, the …
tumorigenesis, tumor progression, and therapy resistance in breast cancer. However, the …
Precise immunodetection of PTEN protein in human neoplasia
R Pulido, J Mingo, A Gaafar… - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
PTEN is a major tumor-suppressor protein whose expression and biological activity are
frequently diminished in sporadic or inherited cancers. PTEN gene deletion or loss-of …
frequently diminished in sporadic or inherited cancers. PTEN gene deletion or loss-of …
Risk stratification of prostate cancer through quantitative assessment of PTEN loss (qPTEN)
Background Phosphatase and tensin homolog (PTEN) loss has long been associated with
adverse findings in early prostate cancer. Studies to date have yet to employ quantitative …
adverse findings in early prostate cancer. Studies to date have yet to employ quantitative …
Heterogeneous expression and subcellular localization of pyruvate dehydrogenase complex in prostate cancer
Background Pyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by
pyruvate decarboxylation, which drives energy metabolism during cell growth, including …
pyruvate decarboxylation, which drives energy metabolism during cell growth, including …
Utilizing PTEN immunohistochemistry as a screening test for Cowden syndrome
Objectives Cowden syndrome (CS) is a multisystem disease with an elevated lifetime risk of
internal malignancy. We aim to assess the role of PTEN immunostain as a screening test for …
internal malignancy. We aim to assess the role of PTEN immunostain as a screening test for …
Chemical and structural approaches to investigate PTEN function and regulation
Phosphatase and tensin homolog is a lipid phosphatase that serves as the major negative
regulator of the PI3K/AKT pathway. It catalyzes the 3′-specific dephosphorylation of …
regulator of the PI3K/AKT pathway. It catalyzes the 3′-specific dephosphorylation of …
Impact of B7-H3 expression on metastasis, immune exhaustion and JAK/STAT and PI3K/AKT pathways in clear cell renal cell carcinoma
M Emaldi, E Rey-Iborra, Á Marín, L Mosteiro… - …, 2024 - Taylor & Francis
Immune checkpoint inhibitors in combination with tyrosine kinase inhibitors (TKIs) are
improving the response rates of advanced renal cancer patients. However, many treated …
improving the response rates of advanced renal cancer patients. However, many treated …
Novel anti-PTEN C2 domain monoclonal antibodies to analyse the expression and function of PTEN isoform variants
PTEN is a major tumor suppressor gene frequently mutated in human tumors, and germline
PTEN gene mutations are the molecular diagnostic of PTEN Hamartoma Tumor Syndrome …
PTEN gene mutations are the molecular diagnostic of PTEN Hamartoma Tumor Syndrome …