Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

The Polycomb system modifies chromatin and plays an essential role in repressing gene
expression to control normal mammalian development. However, the components and …

The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …

Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …

Poised enhancers marked by H3K27me3 in pluripotent stem cells have been implicated in
the establishment of somatic expression programs during embryonic stem cell (ESC) …

Modulation of chromatin structure and/or modification by Polycomb repressive complexes
(PRCs) provides an important means to partition the genome into functionally distinct …

Although the core subunits of Polycomb group (PcG) complexes are well characterized, little
is known about the dynamics of these protein complexes during cellular differentiation. We …