Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

ND Donahue, H Acar, S Wilhelm - Advanced drug delivery reviews, 2019 - Elsevier
Nanoparticle-based therapeutics and diagnostics are commonly referred to as
nanomedicine and may significantly impact the future of healthcare. However, the clinical …

Understanding cell penetration of cyclic peptides

PG Dougherty, A Sahni, D Pei - Chemical Reviews, 2019 - ACS Publications
Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Bioactive peptides

EBM Daliri, DH Oh, BH Lee - Foods, 2017 - mdpi.com
The increased consumer awareness of the health promoting effects of functional foods and
nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive …

Cell-penetrating peptides: design, synthesis, and applications

DM Copolovici, K Langel, E Eriste, U Langel - ACS nano, 2014 - ACS Publications
The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

[HTML][HTML] Cell-penetrating peptides: 20 years later, where do we stand?

C Bechara, S Sagan - FEBS letters, 2013 - Elsevier
Twenty years ago, the discovery of peptides able to cross cellular membranes launched a
novel field in molecular delivery based on these non-invasive vectors, most commonly …

Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy

X Guo, X Wei, Z Chen, X Zhang, G Yang… - Progress in Materials …, 2020 - Elsevier
To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …

Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore

C Allolio, A Magarkar, P Jurkiewicz… - Proceedings of the …, 2018 - National Acad Sciences
Arginine-rich cell-penetrating peptides do not enter cells by directly passing through a lipid
membrane; they instead passively enter vesicles and live cells by inducing membrane …

Mechanisms of cellular uptake of cell‐penetrating peptides

F Madani, S Lindberg, Ü Langel, S Futaki… - Journal of …, 2011 - Wiley Online Library
Recently, much attention has been given to the problem of drug delivery through the cell‐
membrane in order to treat and manage several diseases. The discovery of cell penetrating …

Membrane active peptides and their biophysical characterization

FG Avci, B Sariyar Akbulut, E Ozkirimli - Biomolecules, 2018 - mdpi.com
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

Cell penetrating peptides: the potent multi-cargo intracellular carriers

K Kardani, A Milani, S H. Shabani… - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …