Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases

T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

A materials-science perspective on tackling COVID-19

Z Tang, N Kong, X Zhang, Y Liu, P Hu, S Mou… - Nature Reviews …, 2020 - nature.com
The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in
providing tools and technologies for antiviral research and treatment development. In this …

Learning the protein language: Evolution, structure, and function

T Bepler, B Berger - Cell systems, 2021 - cell.com
Language models have recently emerged as a powerful machine-learning approach for
distilling information from massive protein sequence databases. From readily available …

Super-resolution microscopy for structural cell biology

S Liu, P Hoess, J Ries - Annual review of biophysics, 2022 - annualreviews.org
Super-resolution microscopy techniques, and specifically single-molecule localization
microscopy (SMLM), are approaching nanometer resolution inside cells and thus have great …

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

Y Watanabe, ZT Berndsen, J Raghwani… - Nature …, 2020 - nature.com
Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS)
coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic …

Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs

T Bepler, A Morin, M Rapp, J Brasch, L Shapiro… - Nature …, 2019 - nature.com
Cryo-electron microscopy is a popular method for the determination of protein structures;
however, identifying a sufficient number of particles for analysis can take months of manual …

Opportunities and obstacles for deep learning in biology and medicine

T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …

cisTEM, user-friendly software for single-particle image processing

T Grant, A Rohou, N Grigorieff - elife, 2018 - elifesciences.org
We have developed new open-source software called cis TEM (computational imaging
system for transmission electron microscopy) for the processing of data for high-resolution …

Electron microscopy studies of soft nanomaterials

Z Lyu, L Yao, W Chen, FC Kalutantirige… - Chemical …, 2023 - ACS Publications
This review highlights recent efforts on applying electron microscopy (EM) to soft (including
biological) nanomaterials. We will show how developments of both the hardware and …

Super-resolution microscopy with DNA-PAINT

J Schnitzbauer, MT Strauss, T Schlichthaerle… - Nature protocols, 2017 - nature.com
Super-resolution techniques have begun to transform biological and biomedical research by
allowing researchers to observe structures well below the classic diffraction limit of light …