The biogenesis, folding, and structure of α-helical membrane proteins (MPs) are important to
understand because they underlie virtually all physiological processes in cells including key …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

GPER is a G s-coupled seven-transmembrane receptor that has been linked to specific
estrogen binding and signaling activities that are manifested by plasma membrane …

The majority of preproteins destined for mitochondria carry N-terminal presequences. The
presequence translocase of the inner mitochondrial membrane (TIM23 complex) plays a …

Production and trafficking of proteins entering the secretory pathway of eukaryotic cells is
coordinated at the endoplasmic reticulum (ER) in a process that begins with protein …

Cell-surface multiprotein complexes are synthesized in the endoplasmic reticulum (ER),
where they undergo cotranslational membrane integration and assembly. The quality control …

Astrocyte elevated gene-1 (AEG-1), an oncogene whose overexpression promotes tumor
cell proliferation, angiogenesis, invasion, and enhanced chemoresistance, is thought to …

Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …

Folding of membrane proteins begins in the ribosome as the peptide is elongated. During
this process, the nascent peptide navigates along 100 Å of tunnel from the …