Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Breast cancer (BC) is the most commonly diagnosed form of cancer and a leading cause of
cancer-related deaths among women worldwide. Yes-associated protein (YAP) and …

Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …

The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes
breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in …

The E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a
member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 …

The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive
BC. Despite intensive efforts to improve BC treatments, patients with TN BC continue to …

Out of the breast cancer subtypes, triple-negative breast cancer (TNBC) has the poorest
prognosis without effective targeted therapies. Metformin, a first-line drug for type 2 diabetes …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

Ephrin type-A receptor 2 (EphA2) is a member of the tyrosine receptor kinases, a family of
membrane proteins recognized as potential anticancer targets. EphA2 highly expressed in a …