Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

The American Diabetes Association, JDRF, the European Association for the Study of
Diabetes, and the American Association of Clinical Endocrinologists convened a research …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

A wealth of data and comprehensive reviews exist on pancreas development in mammals,
primarily mice, and other vertebrates. By contrast, human pancreatic development has been …

DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the
insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in …