Cancer treatment is undergoing a significant revolution from “one‐size‐fits‐all” cytotoxic
therapies to tailored approaches that precisely target molecular alterations. Precision …

Breast cancer is one of the major causes of cancer death in women. Many studies have
sought to identify specific molecules involved in breast cancer and understand their …

Background: DNA methylation is a common event in the early development of various
tumors, including breast cancer (BRCA), which has been studies as potential tumor …

Background DNA methylation is the major form of epigenetic modifications through which
the cell regulates the gene expression and silencing. There have been extensive studies on …

In this paper we propose a novel statistic, the smooth Euler characteristic transform (SECT).
The SECT is designed to integrate shape information into standard statistical models. More …

Motivation DNA methylation plays an important role in many biological processes and
cancer progression. Recent studies have found that there are also differences in methylation …

Highlights•Obesity is a risk factor for breast cancer, but the relationship is not simple.•Obesity
is associated with epigenetic alterations involving DNA methylation.•Breast cancer is …

Papillary thyroid carcinoma (PTC) is the most common malignant tumor of endocrine
systems. Chromosomal instability (CIN) is crucial to the clinical prognoses of tumor patients …

Introduction: Signal transducers and activators of transcription (STATs) are members of
conserved transcription factors family, and deregulated STAT family members are closely …

The main contribution of this thesis is to examine the utility of kernel regression approaches
and variance component models for solving complex problems in statistical genetics and …