Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Cancer cells rewire their metabolism to survive during cancer progression. In this context,
tumour metabolic heterogeneity arises and develops in response to diverse environmental …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

In the last decades, the role of the microenvironment in tumor progression and therapeutic
outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have …

Nanoparticles (NPs) are confronted with limited and disappointing delivery efficiency in
tumors clinically. The tumor extracellular matrix (ECM), whose physical traits have recently …

As a major component of the human body, the extracellular matrix (ECM) is a complex
biopolymer network. The ECM not only hosts a plethora of biochemical interactions but also …

The production and release of tumor-derived small extracellular vesicles (TDSEVs) from
cancerous cells play a pivotal role in the propagation of cancer, through genetic and …