Rethinking retrosplenial cortex: Perspectives and predictions

AS Alexander, R Place, MJ Starrett, ER Chrastil… - Neuron, 2023 - cell.com
The last decade has produced exciting new ideas about retrosplenial cortex (RSC) and its
role in integrating diverse inputs. Here, we review the diversity in forms of spatial and …

Theory of the multiregional neocortex: large-scale neural dynamics and distributed cognition

XJ Wang - Annual review of neuroscience, 2022 - annualreviews.org
The neocortex is a complex neurobiological system with many interacting regions. How
these regions work together to subserve flexible behavior and cognition has become …

Spatiotemporal dynamics of noradrenaline during learned behaviour

V Breton-Provencher, GT Drummond, J Feng, Y Li… - Nature, 2022 - nature.com
Noradrenaline released from the locus coeruleus (LC) is a ubiquitous neuromodulator,,–that
has been linked to multiple functions including arousal,,–, action and sensory gain,–, and …

Meta-reinforcement learning via orbitofrontal cortex

R Hattori, NG Hedrick, A Jain, S Chen, H You… - Nature …, 2023 - nature.com
The meta-reinforcement learning (meta-RL) framework, which involves RL over multiple
timescales, has been successful in training deep RL models that generalize to new …

Value-guided remap** of sensory cortex by lateral orbitofrontal cortex

A Banerjee, G Parente, J Teutsch, C Lewis, FF Voigt… - Nature, 2020 - nature.com
Adaptive behaviour crucially depends on flexible decision-making, which in mammals relies
on the frontal cortex, specifically the orbitofrontal cortex (OFC),,,,,,,–. How OFC encodes …

Serotonin neurons modulate learning rate through uncertainty

CD Grossman, BA Bari, JY Cohen - Current Biology, 2022 - cell.com
Regulating how fast to learn is critical for flexible behavior. Learning about the
consequences of actions should be slow in stable environments, but accelerate when that …

Cell-type-specific population dynamics of diverse reward computations

EL Sylwestrak, YJ Jo, S Vesuna, X Wang, B Holcomb… - Cell, 2022 - cell.com
Computational analysis of cellular activity has developed largely independently of modern
transcriptomic cell typology, but integrating these approaches may be essential for full …

Genetic map** of etiologic brain cell types for obesity

PN Timshel, JJ Thompson, TH Pers - Elife, 2020 - elifesciences.org
The underlying cell types mediating predisposition to obesity remain largely obscure. Here,
we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 …

Characterizing cortex-wide dynamics with wide-field calcium imaging

C Ren, T Komiyama - Journal of Neuroscience, 2021 - jneurosci.org
The brain functions through coordinated activity among distributed regions. Wide-field
calcium imaging, combined with improved genetically encoded calcium indicators, allows …

[HTML][HTML] An Integrated World Modeling Theory (IWMT) of consciousness: combining integrated information and global neuronal workspace theories with the free …

A Safron - Frontiers in artificial intelligence, 2020 - frontiersin.org
The Free Energy Principle and Active Inference Framework (FEP-AI) begins with the
understanding that persisting systems must regulate environmental exchanges and prevent …