Recent neurophysiological and neuroanatomical studies suggest a close interaction
between sensory and motor processes across the neocortex. Here, I propose that the …

The midline and intralaminar nuclei of the thalamus form a major part of the “limbic
thalamus;” that is, thalamic structures anatomically and functionally linked with the limbic …

Current concepts of corticothalamic organization in the mammalian brain are mainly based
on sensory systems, with less focus on circuits for higher-order cognitive functions. In …

Corticothalamic pathways, responsible for the top-down control of the thalamus, have a
canonical organization such that every cortical region sends output from both layer 6 (L6) …

All pathways targeting the thalamus terminate directly onto the thalamic projection cells. As
these cells lack local excitatory interconnections, their computations are fundamentally …

It has become widely accepted that humans use contextual information to infer the meaning
of ambiguous acoustic signals. In speech, for example, high-level semantic, syntactic, or …

The corticothalamic (CT) pathways emanate from either Layer 5 (L5) or 6 (L6) of the
neocortex and largely outnumber the ascending, thalamocortical pathways. The CT …

For animals to survive, they must interact with their environment, taking in sensory
information and making appropriate motor responses. Early on during vertebrate evolution …

Interactions across frontal cortex are critical for cognition. Animal studies suggest a role for
mediodorsal thalamus (MD) in these interactions, but the computations performed and direct …

Parkinson's disease (PD) is one of the most common chronic progressive
neurodegenerative diseases that affects both motor and non-motor functions. Bile acids …