The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Forkhead box (FOX) O proteins are transcription factors (TFs) with four members in
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …

FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

The accumulation of irreparable cellular damage restricts healthspan after acute stress or
natural aging. Senescent cells are thought to impair tissue function, and their genetic …

FOXO family of proteins are transcription factors involved in many physiological and
pathological processes including cellular homeostasis, stem cell maintenance, cancer …

The coordinated regulation between cellular glucose uptake and endogenous glucose
production is indispensable for the maintenance of constant blood glucose concentrations …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin
resistance and associated with several sequelae of metabolic syndrome in humans …

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

In the mammalian intestine, crypts of Leiberkühn house intestinal epithelial stem/progenitor
cells at their base. The mammalian intestine also harbors a diverse array of microbial …