The sensory, associative and limbic neocortical structures play a critical role in sha**
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

Over the past 20 years, clinical and preclinical studies point to the anterior cingulate cortex
(ACC) as a site of interest for several neurological and psychiatric conditions. The ACC …

The primary objective of preclinical pain research is to improve the treatment of pain.
Decades of research using pain-evoked tests has revealed much about mechanisms but …

Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …

Pain is an integrated sensory and affective experience. Cortical mechanisms of sensory and
affective integration, however, remain poorly defined. Here, we investigate the projection …

Effective treatments for chronic pain remain limited. Conceptually, a closed-loop neural
interface combining sensory signal detection with therapeutic delivery could produce timely …

Chronic pain is characterized by discrete pain episodes of unpredictable frequency and
duration. This hinders the study of pain mechanisms and contributes to the use of …

The central mechanisms underlying pain chronicity remain elusive. Here, we identify a
reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the …

The anterior cingulate cortex (ACC) is thought to be important for acute pain perception as
well as the development of chronic pain after peripheral nerve injury. Nevertheless, how …

Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …