Hepatocellular carcinoma (HCC), the most commonly diagnosed primary liver cancer, has
become a leading cause of cancer-related death worldwide. Accumulating evidence …

The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype
demonstrates great potential for remodeling the immunosuppressive tumor …

Despite significant treatment efforts, pancreatic ductal adenocarcinoma (PDAC), the
deadliest solid tumor, is still incurable in the preclinical stages due to multifacet stroma …

Understanding the mechanism and progression of neutrophil-involved diseases (eg, acute
inflammation) is of great importance. However, current available analytical methods neither …

The prognosis in cases of pancreatic ductal adenocarcinoma (PDAC) with current treatment
modalities is poor owing to the highly desmoplastic tumor microenvironment (TME). Herein …

The critical role of tumor microenvironment (TME) in tumor initiation and development has
been well-recognized after more than a century of studies. Numerous therapeutic …

Misguided attack of immune systems on self-tissue or multifactorial uncontrolled
inflammation is capable of causing inflammatory diseases. Neutrophils play a critical role in …

Heterogeneous structured nanomaterials can be considered as a class of advanced
materials that integrate multiple phases, different elements, or components into a single …

The immune resistance of tumor microenvironment (TME) causes immune checkpoint
blockade therapy inefficient to hepatocellular carcinoma (HCC). Emerging strategies of …

Pancreatic cancer remains one of the deadliest cancers with extremely high mortality rate,
and the number of cases is expected to steadily increase with time. Pancreatic cancer is …