Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow
Temporal changes in blood flow are commonly observed in malignant tumours, but the
evolutionary causes and consequences are rarely considered. We propose that stochastic …
evolutionary causes and consequences are rarely considered. We propose that stochastic …
Using chronobiology-based second-generation artificial intelligence digital system for overcoming antimicrobial drug resistance in chronic infections
Y Kolben, H Azmanov, R Gelman, D Dror… - Annals of Medicine, 2023 - Taylor & Francis
Antimicrobial resistance results from the widespread use of antimicrobial agents and is a
significant obstacle to the effectiveness of these agents. Numerous methods are used to …
significant obstacle to the effectiveness of these agents. Numerous methods are used to …
Spatial heterogeneity and evolutionary dynamics modulate time to recurrence in continuous and adaptive cancer therapies
Abstract Treatment of advanced cancers has benefited from new agents that supplement or
bypass conventional therapies. However, even effective therapies fail as cancer cells deploy …
bypass conventional therapies. However, even effective therapies fail as cancer cells deploy …
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer
therapy today. However, evolving resistance to one drug may come at a cost of decreased …
therapy today. However, evolving resistance to one drug may come at a cost of decreased …
Phenotypic heterogeneity in human genetic diseases: ultrasensitivity-mediated threshold effects as a unifying molecular mechanism
YH Sun, YL Wu, BY Liao - Journal of Biomedical Science, 2023 - Springer
Phenotypic heterogeneity is very common in genetic systems and in human diseases and
has important consequences for disease diagnosis and treatment. In addition to the many …
has important consequences for disease diagnosis and treatment. In addition to the many …
Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer
Drug resistance remains an elusive problem in cancer therapy, particularly for novel
targeted therapies. Much work is focused upon the development of an arsenal of targeted …
targeted therapies. Much work is focused upon the development of an arsenal of targeted …
Understanding the role of phenotypic switching in cancer drug resistance
The emergence of acquired drug resistance in cancer represents a major barrier to
treatment success. While research has traditionally focused on genetic sources of …
treatment success. While research has traditionally focused on genetic sources of …
Cross-resistance among sequential cancer therapeutics: an emerging issue
Over the past two decades, cancer treatment has benefited from having a significant
increase in the number of targeted drugs approved by the United States Food and Drug …
increase in the number of targeted drugs approved by the United States Food and Drug …
Multivalent state transitions shape the intratumoral composition of small cell lung carcinoma
Studies to date have not resolved how diverse transcriptional programs contribute to the
intratumoral heterogeneity of small cell lung carcinoma (SCLC), an aggressive tumor …
intratumoral heterogeneity of small cell lung carcinoma (SCLC), an aggressive tumor …
Antifragility in complex dynamical systems
Antifragility characterizes the benefit of a dynamical system derived from the variability in
environmental perturbations. Antifragility carries a precise definition that quantifies a …
environmental perturbations. Antifragility carries a precise definition that quantifies a …