Mechanical properties and peculiarities of molecular crystals

WM Awad, DW Davies, D Kitagawa… - Chemical Society …, 2023 - pubs.rsc.org
In the last century, molecular crystals functioned predominantly as a means for determining
the molecular structures via X-ray diffraction, albeit as the century came to a close the …

Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review

A Moeini, P Pedram, P Makvandi, M Malinconico… - Carbohydrate …, 2020 - Elsevier
Wound healing can lead to complex clinical problems, hence finding an efficient approach to
enhance the healing process is necessary. An ideal wound dressing should treat wounds at …

[HTML][HTML] Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

H Mei, S Cai, D Huang, H Gao, J Cao, B He - Bioactive materials, 2022 - Elsevier
The considerable development of carrier-free nanodrugs has been achieved due to their
high drug-loading capability, simple preparation method, and offering “all-in-one” functional …

Terpenoids' anti-cancer effects: Focus on autophagy

C El-Baba, A Baassiri, G Kiriako, B Dia, S Fadlallah… - Apoptosis, 2021 - Springer
Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

[HTML][HTML] Towards principled design of cancer nanomedicine to accelerate clinical translation

M Souri, M Soltani, FM Kashkooli, MK Shahvandi… - Materials Today Bio, 2022 - Elsevier
Nanotechnology in medical applications, especially in oncology as drug delivery systems,
has recently shown promising results. However, although these advances have been …

Application of ensemble machine learning approach to assess the factors affecting size and polydispersity index of liposomal nanoparticles

B Hoseini, MR Jaafari, A Golabpour… - Scientific Reports, 2023 - nature.com
Liposome nanoparticles have emerged as promising drug delivery systems due to their
unique properties. Assessing particle size and polydispersity index (PDI) is critical for …

Drug solubility: importance and enhancement techniques

KT Savjani, AK Gajjar, JK Savjani - … Scholarly Research Notices, 2012 - Wiley Online Library
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system,
is one of the important parameters to achieve desired concentration of drug in systemic …

Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

PLGA-based nanoparticles: an overview of biomedical applications

F Danhier, E Ansorena, JM Silva, R Coco… - Journal of controlled …, 2012 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successfully developed
biodegradable polymers. Among the different polymers developed to formulate polymeric …

[HTML][HTML] Overview of milling techniques for improving the solubility of poorly water-soluble drugs

ZH Loh, AK Samanta, PWS Heng - Asian journal of pharmaceutical …, 2015 - Elsevier
Milling involves the application of mechanical energy to physically break down coarse
particles to finer ones and is regarded as a “top–down” approach in the production of fine …