Repair of the infarcted heart: cellular effectors, molecular mechanisms and therapeutic opportunities
The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …
[HTML][HTML] The macrophage–fibroblast dipole in the context of cardiac repair and fibrosis
S Psarras - Biomolecules, 2024 - mdpi.com
Stromal and immune cells and their interactions have gained the attention of cardiology
researchers and clinicians in recent years as their contribution in cardiac repair is …
researchers and clinicians in recent years as their contribution in cardiac repair is …
Emerging Anti-Inflammatory COPD Treatments: Potential Cardiovascular Impacts
M Cazzola, L Calzetta, P Rogliani… - International Journal of …, 2024 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition
often complicated by cardiovascular disease (CVD) due to shared inflammatory pathways …
often complicated by cardiovascular disease (CVD) due to shared inflammatory pathways …
Macrophages modulate fibrosis during newt lens regeneration
G Tsissios, A Sallese, JR Perez-Estrada… - Stem Cell Research & …, 2024 - Springer
Background Previous studies have suggested that macrophages are present during lens
regeneration in newts, but their role in the process is yet to be elucidated. Methods Here we …
regeneration in newts, but their role in the process is yet to be elucidated. Methods Here we …
Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans
S Alvarez-Argote, VA Almeida… - American Journal …, 2024 - journals.physiology.org
Ischemic heart failure continues to be a highly prevalent disease among westernized
countries and there is great interest in understanding the mechanisms preventing or …
countries and there is great interest in understanding the mechanisms preventing or …
Negative regulator IL-1 receptor 2 (IL-1R2) and its roles in immune regulation of autoimmune diseases
Y Zhang, K Liu, M Guo, Y Yang, H Zhang - International …, 2024 - Elsevier
The decoy receptor interleukin 1 receptor 2 (IL-1R2), also known as CD121b, has different
forms: membrane-bound (mIL-1R2), soluble secreted (ssIL-1R2), shedded (shIL-1R2) …
forms: membrane-bound (mIL-1R2), soluble secreted (ssIL-1R2), shedded (shIL-1R2) …
Causal role of circulating inflammatory cytokines in cardiac diseases, structure and function
W Ruan, X Zhou, H Liu, T Wang, G Zhang, K Lin - Heart & Lung, 2024 - Elsevier
Background Inflammation is implicated in cardiovascular disease (CVD) pathogenesis, but
causal roles of specific circulating inflammatory cytokines remain unclear. Mendelian …
causal roles of specific circulating inflammatory cytokines remain unclear. Mendelian …
Scratching beneath the surface: IL4Rα blockade and the progression from myocardial ischemic injury to heart failure
13 Ischemic heart disease (IHD) and its clinical manifestations of acute myocardial infarction
(MI) 14 and ischemic cardiomyopathy are the leading cause of death worldwide1, 2. In the …
(MI) 14 and ischemic cardiomyopathy are the leading cause of death worldwide1, 2. In the …