Tuberculosis—metabolism and respiration in the absence of growth
HIM Boshoff, CE Barry 3rd - Nature Reviews Microbiology, 2005 - nature.com
Human tuberculosis is a complex disease caused by bacterial populations that are located
in discrete lesions (microenvironments) in a single host. Some of these microenvironments …
in discrete lesions (microenvironments) in a single host. Some of these microenvironments …
Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy
The global tuberculosis (TB) control effort is focused on interrupting transmission of the
causative agent, Mycobacterium tuberculosis, through chemotherapeutic intervention in …
causative agent, Mycobacterium tuberculosis, through chemotherapeutic intervention in …
Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis
Antibiotic resistance of Mycobacterium tuberculosis is exclusively a consequence of
chromosomal mutations. Translesion synthesis (TLS) is a widely conserved mechanism of …
chromosomal mutations. Translesion synthesis (TLS) is a widely conserved mechanism of …
Morphological profiling of tubercle bacilli identifies drug pathways of action
Morphological profiling is a method to classify target pathways of antibacterials based on
how bacteria respond to treatment through changes to cellular shape and spatial …
how bacteria respond to treatment through changes to cellular shape and spatial …
Biomarkers of cell-mediated immunity to bovine tuberculosis
Whole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs),
are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the …
are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the …
DNA repair in Mycobacterium tuberculosis revisited
T Dos Vultos, O Mestre, T Tonjum… - FEMS microbiology …, 2009 - academic.oup.com
Our understanding of Mycobacterium tuberculosis DNA repair mechanisms is still poor
compared with that of other bacterial organisms. However, the publication of the first …
compared with that of other bacterial organisms. However, the publication of the first …
A new evolutionary and pharmacokinetic–pharmacodynamic scenario for rapid emergence of resistance to single and multiple anti-tuberculosis drugs
JG Pasipanodya, T Gumbo - Current opinion in pharmacology, 2011 - Elsevier
The current understanding of the mechanism of anti-tuberculosis drug resistance has been
shaped by the history of development of anti-tuberculosis drugs in the past 60 years and …
shaped by the history of development of anti-tuberculosis drugs in the past 60 years and …
The BER necessities: the repair of DNA damage in human-adapted bacterial pathogens
S Van Der Veen, CM Tang - Nature Reviews Microbiology, 2015 - nature.com
During colonization and disease, bacterial pathogens must survive the onslaught of the host
immune system. A key component of the innate immune response is the generation of …
immune system. A key component of the innate immune response is the generation of …
Comparative genomics of metabolic pathways in Mycobacterium species: gene duplication, gene decay and lateral gene transfer
PR Marri, JP Bannantine… - FEMS microbiology …, 2006 - academic.oup.com
The genus Mycobacterium comprises significant pathogenic species that infect both humans
and animals. One species within this genus, Mycobacterium tuberculosis, is the primary …
and animals. One species within this genus, Mycobacterium tuberculosis, is the primary …
The non-clonality of drug resistance in Bei**g-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa
Abstract Background The Bei**g genotype of M. tuberculosis is a virulent strain that is
disseminating worldwide and has a strong association with drug resistance. In the Western …
disseminating worldwide and has a strong association with drug resistance. In the Western …