Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as
cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term …

Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …

Mitochondrial dysfunction is becoming one of the most emerging pathological process in the
etiology of neurological disorders. Other common etiologies of the neurological disorders …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …