Metabolic basis of creatine in health and disease: a bioinformatics-assisted review

DA Bonilla, RB Kreider, JR Stout, DA Forero… - Nutrients, 2021 - mdpi.com
Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and
pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target …

Creatine supplementation with specific view to exercise/sports performance: an update

R Cooper, F Naclerio, J Allgrove, A Jimenez - Journal of the International …, 2012 - Springer
Creatine is one of the most popular and widely researched natural supplements. The
majority of studies have focused on the effects of creatine monohydrate on performance and …

TREM2 maintains microglial metabolic fitness in Alzheimer's disease

TK Ulland, WM Song, SCC Huang, JD Ulrich… - Cell, 2017 - cell.com
Elevated risk of develo** Alzheimer's disease (AD) is associated with hypomorphic
variants of TREM2, a surface receptor required for microglial responses to …

“Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function

DG Candow, SC Forbes, SM Ostojic, K Prokopidis… - Sports Medicine, 2023 - Springer
There is emerging interest regarding the potential beneficial effects of creatine
supplementation on indices of brain health and function. Creatine supplementation can …

Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?

PJ Allen - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
Athletes, body builders, and military personnel use dietary creatine as an ergogenic aid to
boost physical performance in sports involving short bursts of high-intensity muscle activity …

Creatine: endogenous metabolite, dietary, and therapeutic supplement

JT Brosnan, ME Brosnan - Annu. Rev. Nutr., 2007 - annualreviews.org
Creatine and phosphocreatine serve not only as an intracellular buffer for adenosine
triphosphate, but also as an energy shuttle for the movement of high-energy phosphates …

Synthesis and transport of creatine in the CNS: importance for cerebral functions

E Béard, O Braissant - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 115, 297–313. Abstract Apart of its well known function of 'energetic
buffer'through the creatine/phosphocreatine/creatine kinase system allowing the …

Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?

M Wyss, A Schulze - Neuroscience, 2002 - Elsevier
Major achievements made over the last several years have highlighted the important roles of
creatine and the creatine kinase reaction in health and disease. Inborn errors of metabolism …

Creatine metabolism in female reproduction, pregnancy and newborn health

AM Muccini, NT Tran, DL de Guingand, M Philip… - Nutrients, 2021 - mdpi.com
Creatine metabolism is an important component of cellular energy homeostasis. Via the
creatine kinase circuit, creatine derived from our diet or synthesized endogenously provides …

Current perspective of mitochondrial biology in Parkinson's disease

NA Kaidery, B Thomas - Neurochemistry International, 2018 - Elsevier
Parkinson's disease (PD) is one of the most common neurodegenerative movement disorder
characterized by preferential loss of dopaminergic neurons of the substantia nigra pars …