Integrin trafficking in cells and tissues
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …
Integrin-Dependent Cell–Matrix Adhesion in Endothelial Health and Disease
J Aman, C Margadant - Circulation Research, 2023 - Am Heart Assoc
The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating
blood vessel formation and barrier function. Proper composition and function of the …
blood vessel formation and barrier function. Proper composition and function of the …
ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation
M Tian, F Hao, X **, X Sun, Y Jiang, Y Wang, D Li… - Elife, 2021 - elifesciences.org
Inducible regulatory T (iTreg) cells play a central role in immune suppression. As iTreg cells
are differentiated from activated T (Th0) cells, cell metabolism undergoes dramatic changes …
are differentiated from activated T (Th0) cells, cell metabolism undergoes dramatic changes …
Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation
W Dubiel, D Dubiel, DA Wolf, M Naumann - Trends in biochemical …, 2018 - cell.com
Specificity of the ubiquitin proteasome system is controlled by ubiquitin E3 ligases, including
their major representatives, the multisubunit cullin-RING ubiquitin (Ub) ligases (CRLs). More …
their major representatives, the multisubunit cullin-RING ubiquitin (Ub) ligases (CRLs). More …
Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians
Background Observational studies have revealed that type 2 diabetes (T2D) is associated
with an increased risk of peripheral artery disease (PAD). However, whether the two …
with an increased risk of peripheral artery disease (PAD). However, whether the two …
CRL3s: the BTB-CUL3-RING E3 ubiquitin ligases
The ubiquitin proteasome pathway is one of the major regulatory tools used by eukaryotic
cells. The evolutionarily conserved cullin family proteins can assemble as many as> 600 …
cells. The evolutionarily conserved cullin family proteins can assemble as many as> 600 …
Cullin‐3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2‐positive breast cancer cells
A Murakami, M Maekawa, K Kawai… - Cancer …, 2019 - Wiley Online Library
Rho GTPase Rac1 is a central regulator of F‐actin organization and signal transduction to
control plasma membrane dynamics and cell proliferation. Dysregulated Rac1 activity is …
control plasma membrane dynamics and cell proliferation. Dysregulated Rac1 activity is …
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP
K Nishiyama, M Maekawa, T Nakagita… - Life Science …, 2021 - life-science-alliance.org
Epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2) phosphorylation
drives HER2-positive breast cancer cell proliferation. Enforced activation of phosphatases …
drives HER2-positive breast cancer cell proliferation. Enforced activation of phosphatases …
Inner nuclear membrane protein, SUN1, is required for cytoskeletal force generation and focal adhesion maturation
The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the inner
nuclear membrane-spanning SUN proteins and the outer nuclear membrane-spanning …
nuclear membrane-spanning SUN proteins and the outer nuclear membrane-spanning …
The roles of SPOP in DNA damage response and DNA replication
M Maekawa, S Higashiyama - International journal of molecular sciences, 2020 - mdpi.com
Speckle-type BTB/POZ protein (SPOP) is a substrate recognition receptor of the cullin-3
(CUL3)/RING type ubiquitin E3 complex. To date, approximately 30 proteins have been …
(CUL3)/RING type ubiquitin E3 complex. To date, approximately 30 proteins have been …