Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment

LD Wood, MI Canto, EM Jaffee, DM Simeone - Gastroenterology, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …

Insights gained from single-cell analysis of immune cells in the tumor microenvironment

X Ren, L Zhang, Y Zhang, Z Li… - Annual review of …, 2021 - annualreviews.org
Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and develo** cancer immunotherapies. Recent applications of …

Molecular Characterization of KRAS Wild-type Tumors in Patients with Pancreatic Adenocarcinoma

PA Philip, I Azar, J ** of pancreatic cancer
X Zhou, K Hu, P Bailey, C Springfeld, S Roth… - Frontiers in cell and …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma is a highly lethal malignancy, which has now become the
seventh most common cause of cancer death in the world, with the highest mortality rates in …

Intraductal papillary mucinous neoplasms arise from multiple independent clones, each with distinct mutations

CG Fischer, VB Guthrie, AM Braxton, L Zheng, P Wang… - Gastroenterology, 2019 - Elsevier
Background & Aims Intraductal papillary mucinous neoplasms (IPMNs) are lesions that can
progress to invasive pancreatic cancer and constitute an important system for studies of …

Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions

K Fujikura, W Hosoda, M Felsenstein, Q Song… - Gut, 2021 - gut.bmj.com
Objective Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor
lesions that can progress to invasive pancreatic cancer and are classified as low-grade or …