An update on the pathological classification of breast cancer

EA Rakha, GM Tse, CM Quinn - Histopathology, 2023‏ - Wiley Online Library
Breast cancer (BC) is a heterogeneous disease, encompassing a diverse spectrum of
tumours with varying morphological, biological, and clinical phenotypes. Although tumours …

[HTML][HTML] Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment

HK Patel, T Bihani - Pharmacology & therapeutics, 2018‏ - Elsevier
Breast cancer is the most frequently diagnosed cancer in women, with estrogen receptor
positive (ER+) breast cancer making up approximately 75% of all breast cancers diagnosed …

circRNA_0025202 regulates tamoxifen sensitivity and tumor progression via regulating the miR-182-5p/FOXO3a axis in breast cancer

Y Sang, B Chen, X Song, Y Li, Y Liang, D Han… - Molecular Therapy, 2019‏ - cell.com
Tamoxifen is the most commonly used endocrine therapy for patients with hormone receptor
(HR)-positive breast cancer. Despite its initial therapeutic efficacy, many patients eventually …

Cancer hallmarks, biomarkers and breast cancer molecular subtypes

X Dai, L **ang, T Li, Z Bai - Journal of cancer, 2016‏ - pmc.ncbi.nlm.nih.gov
Breast cancer is a complex disease encompassing multiple tumor entities, each
characterized by distinct morphology, behavior and clinical implications. Besides estrogen …

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

CS Ross-Innes, R Stark, AE Teschendorff, KA Holmes… - Nature, 2012‏ - nature.com
Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of
breast cancers and its target genes dictate cell growth and endocrine response, yet genomic …

Quantitative MRI radiomics in the prediction of molecular classifications of breast cancer subtypes in the TCGA/TCIA data set

H Li, Y Zhu, ES Burnside, E Huang, K Drukker… - NPJ breast …, 2016‏ - nature.com
Using quantitative radiomics, we demonstrate that computer-extracted magnetic resonance
(MR) image-based tumor phenotypes can be predictive of the molecular classification of …

Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy

A Rani, J Stebbing, G Giamas, J Murphy - Frontiers in endocrinology, 2019‏ - frontiersin.org
The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

Mechanisms of endocrine resistance in breast cancer

CK Osborne, R Schiff - Annual review of medicine, 2011‏ - annualreviews.org
The estrogen receptor (ER) pathway plays a pivotal role in breast cancer development and
progression. Endocrine therapy to block the ER pathway is highly effective, but its …

Molecular classification of breast cancer

D Vuong, PT Simpson, B Green, MC Cummings… - Virchows Archiv, 2014‏ - Springer
Breast cancer is a complex, multifaceted disease encompassing a great variety of entities
that show considerable variation in clinical, morphological and molecular attributes …

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies

XR Yang, J Chang-Claude, EL Goode… - Journal of the …, 2011‏ - academic.oup.com
Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …