Surgical resection plays a central role in the management of gliomas. In this study, we
review the evidence in support of extent of resection to improve survival, symptom …

Glioblastoma (GBM) is the most common primary intracranial neoplasia, and is
characterized by its extremely poor prognosis. Despite maximum surgery, chemotherapy …

Brain tumors are a diverse group of neoplasms that often carry a poor prognosis for patients.
Despite tremendous efforts to develop diagnostic tools and therapeutic avenues, the …

Background While standards for the treatment of newly diagnosed glioblastomas exist,
therapeutic regimens for tumor recurrence remain mostly individualized. The role of a …

Object Despite improvements in the medical and surgical management of patients with
glioblastoma, tumor recurrence remains inevitable. For recurrent glioblastoma, however, the …

Modern glioma surgery has evolved from the principal belief that safe, maximal tumor
resection improves symptom management, quality of life, progression-free survival, and …

Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses
for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work …

Current glioblastoma therapies are insufficient to prevent tumor recurrence and eventual
death. Here, we describe a method to treat malignant glioma by nonviral DNA delivery using …

OBJECTIVE High-grade glioma (HGG) prognosis remains dismal, with inevitable, mostly
local recurrence. Regimens for improving local tumor control are therefore needed …

Background The value of re-resection in recurrent glioblastoma remains controversial as a
randomized trial that specifies intentional incomplete resection cannot be justified ethically …