Excitatory glutamatergic neurotransmission via N-methyl-d-aspartate receptor (NMDAR) is
critical for synaptic plasticity and survival of neurons. However, excessive NMDAR activity …

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …

Reviews the properties of cloned glutamate receptors (GR) and the role of native receptors
in brain diseases and brain injuries. Substantiation for the detrimental role of these receptors …

As a kind of compounds abused in industry productions, phthalic acid esters (PAEs) cause
serious problems in natural environment. PAEs pollution has penetrated into environmental …

The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular
amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

The authors draw together the results of a series of detailed computational studies and show
how they are contributing to the development of a theory of hippocampal function. A new …

The N-methyl D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels
possesses high calcium permeability and unique voltage-dependent sensitivity to …

L-glutamate, the principal excitatory transmitter in the brain, gates ion channels mediating
fast neurotransmission. Subunit components of two related classes of glutamate receptor …