Rat models of spinal cord injury: from pathology to potential therapies
J Kjell, L Olson - Disease models & mechanisms, 2016 - journals.biologists.com
ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …
Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …
Phase 1 safety trial of autologous human schwann cell transplantation in chronic spinal cord injury
A phase 1 open-label, non-randomized clinical trial was conducted to determine feasibility
and safety of autologous human Schwann cell (ahSC) transplantation accompanied by …
and safety of autologous human Schwann cell (ahSC) transplantation accompanied by …
Biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives
S Liu, T Schackel, N Weidner… - Frontiers in cellular …, 2018 - frontiersin.org
Spinal cord injury (SCI), resulting in para-and tetraplegia caused by the partial or complete
disruption of descending motor and ascending sensory neurons, represents a complex …
disruption of descending motor and ascending sensory neurons, represents a complex …
Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial
Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions.
Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk …
Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk …
Exercise-induced plasticity in signaling pathways involved in motor recovery after spinal cord injury
Spinal cord injury (SCI) leads to numerous chronic and debilitating functional deficits that
greatly affect quality of life. While many pharmacological interventions have been explored …
greatly affect quality of life. While many pharmacological interventions have been explored …
Rehabilitation following spinal cord injury: how animal models can help our understanding of exercise-induced neuroplasticity
K Loy, FM Bareyre - Neural regeneration research, 2019 - journals.lww.com
Spinal cord injury is a devastating condition that is followed by long and often unsuccessful
recovery after trauma. The state of the art approach to manage paralysis and concomitant …
recovery after trauma. The state of the art approach to manage paralysis and concomitant …
[BOK][B] Neurological aspects of spinal cord injury
Neurorehabilitation is a newer and smaller subspecialty in neurology and is largely
dominated by neurologists concerned with stroke and brain injury. Spinal cord injury and …
dominated by neurologists concerned with stroke and brain injury. Spinal cord injury and …
A directional 3D neurite outgrowth model for studying motor axon biology and disease
XM Spijkers, S Pasteuning-Vuhman, JC Dorleijn… - Scientific reports, 2021 - nature.com
We report a method to generate a 3D motor neuron model with segregated and directed
axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a …
axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a …
Corticospinal motor circuit plasticity after spinal cord injury: harnessing neuroplasticity to improve functional outcomes
Spinal cord injury (SCI) is a devastating condition that affects approximately 294,000 people
in the USA and several millions worldwide. The corticospinal motor circuitry plays a major …
in the USA and several millions worldwide. The corticospinal motor circuitry plays a major …