Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

Circadian rhythms are near 24-h patterns of physiology and behaviour that are present
independent of external cues including hormones, body temperature, mood, and sleep …

Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative
phosphorylation and generation of ATP, are strongly clock controlled. Here we show that …

Most physiology and behavior of mammalian organisms follow daily oscillations. These
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …

The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals.
Individual SCN neurons in dispersed culture can generate independent circadian …

Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …

The nuclear receptor Rev-erbα regulates circadian rhythm and metabolism, but its effects
are modest and it has been considered to be a secondary regulator of the cell-autonomous …

Objective The aim of this article is to review progress in understanding the mechanisms that
underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of …

The last few years have witnessed a rapid increase in our knowledge of the retinoid-related
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …

Daily rhythms in physiological and behavioral processes are controlled by a network of
circadian clocks, reset by inputs and delivering circadian signals to the brain and peripheral …