This chapter deals with the synthesis of nucleosides (eg, the formation of N‐glycosides of
sugars such as d‐ribose or 2‐deoxy‐D‐ribose with heterocyclic nitrogen bases). The …

Fluorine is one of the most abundant elements on earth. However, it occurs extremely rarely
in biological compounds. Due to the specific properties of fluorine atom (s), including small …

Novel 2 '-deoxycytidine antimetabolites, specifically several 2 '-modified 2 '-deoxy-4 '-
thiocytidines, were synthesized as potential new antineoplastic agents. Methyl 3-O …

Natural and man-made organosulfur compounds play important roles in biological and
medicinal chemistry. 1 Among the various classes of organic sulfur compounds, dihydro-and …

An efficient stereoselective synthesis of 4 '-β-thioribonucleosides 14, 15, 27, and 30 using
the Pummerer reaction as the key step is described. The Pummerer reaction of 1, 4-anhydro …

L-Nucleosides are the enantiomers of the natural nucleosides which have an inverted
configuration at all chiral centers (Fig. 1). By analogy with the natural D-nucleosides, a …

Two strategies were tried to synthesize 3 '-deoxy-3 '-difluoromethyl azanucleosides. After the
failure of the first route, the key intermediate 12 from trans-4-hydroxyproline 7 in 8 steps was …

As 2 ', 3 '-didehydro-2 ', 3 '-dideoxy-2 '-fluoronucleosides have exhibited interesting antiviral
effects against HIV-1 as well as HBV, it is of interest to synthesize the isosterically substituted …

l-Enantiomers of 4′-thioarabinofuranosyl pyrimidine nucleosides were synthesized from d-
xylose. Methyl 2, 3, 5-tri-O-benzyl-d-xylofuranoside 6 was converted to the corresponding …

β-l-2 ', 3 '-Didehydro-2 ', 3 '-dideoxy-2 '-fluoro-4 '-thionucleosides (β-l-2 '-F-4 '-S-d4Ns) have
been synthesized and evaluated against HIV-1 in primary human lymphocytes. The key …