Microbial regulation of host physiology by short-chain fatty acids
Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …
today. Thus, from an evolutionary perspective the human genome and its physiological and …
The molecular hallmarks of epigenetic control
CD Allis, T Jenuwein - Nature Reviews Genetics, 2016 - nature.com
Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …
associated mechanisms that alter chromatin in response to physiological or pathological …
Targeting macrophages: therapeutic approaches in cancer
L Cassetta, JW Pollard - Nature reviews Drug discovery, 2018 - nature.com
Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …
A review of neutrophil extracellular traps (NETs) in disease: potential anti-NETs therapeutics
V Mutua, LJ Gershwin - Clinical reviews in allergy & immunology, 2021 - Springer
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …
[HTML][HTML] Pan-cancer patterns of somatic copy number alteration
Determining how somatic copy number alterations (SCNAs) promote cancer is an important
goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas …
goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas …
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
DE Scott, AR Bayly, C Abell, J Skidmore - Nature Reviews Drug …, 2016 - nature.com
Protein–protein interactions (PPIs) are of pivotal importance in the regulation of biological
systems and are consequently implicated in the development of disease states. Recent work …
systems and are consequently implicated in the development of disease states. Recent work …
Epigenetic regulation by gut microbiota
V Woo, T Alenghat - Gut microbes, 2022 - Taylor & Francis
The gastrointestinal tract is continuously exposed to trillions of commensal microbes,
collectively termed the microbiota, which are environmental stimuli that can direct health and …
collectively termed the microbiota, which are environmental stimuli that can direct health and …
Histone modifications and cancer
JE Audia, RM Campbell - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
The roles of DNA, RNA and histone methylation in ageing and cancer
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …
and RNA. The methylation of chromatin components is highly conserved as it helps …
[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …