Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

L Yu, G Zhu, Z Zhang, Y Yu, L Zeng, Z Xu… - Journal of …, 2023 - Springer
Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis.
Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells …

Apoptotic Vesicles: Therapeutic Mechanisms and Critical Issues

Q Ou, W Huang, B Wang, L Niu, Z Li… - Journal of Dental …, 2024 - journals.sagepub.com
Apoptosis is the most prominent mode of programmed cell death and is necessary for the
maintenance of tissue homeostasis. During cell apoptosis, a distinctive population of …

Hepatocyte-derived tissue extracellular vesicles safeguard liver regeneration and support regenerative therapy

SQ Ying, Y Cao, ZK Zhou, XY Luo, XH Zhang… - Journal of …, 2024 - Springer
Tissue-derived extracellular vesicles (EVs) are emerging as pivotal players to maintain
organ homeostasis, which show promise as a next-generation candidate for medical use …

In situ hydrogel enhances non-efferocytic phagocytosis for post-surgical tumor treatment

J Lyu, H Liu, L Chen, C Liu, J Tao, Y Yao, L Li… - Journal of Controlled …, 2023 - Elsevier
Post-surgical efferocytosis of tumor associated macrophages (TAMs) originates an
immunosuppressive tumor microenvironment and facilitates abscopal metastasis of residual …

Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

X Ma, T Huang, X Chen, Q Li, M Liao, L Fu… - … and Targeted Therapy, 2025 - nature.com
Liver repair and regeneration are crucial physiological responses to hepatic injury and are
orchestrated through intricate cellular and molecular networks. This review systematically …

Beyond host defense and tissue injury: the emerging role of neutrophils in tissue repair

SA Rizo-Téllez, JG Filep - American Journal of Physiology …, 2024 - journals.physiology.org
Neutrophils, the most abundant immune cells in human blood, play a fundamental role in
host defense against invading pathogens and tissue injury. Neutrophils carry potentially …

[HTML][HTML] Microbiota transfer following liver surgery involves microbial extracellular vesicle migration that affects liver immunity

SJ Cohen, G Meyerovich, S Blank… - Hepatology …, 2023 - journals.lww.com
The perioperative probiotic intervention involves gut/liver communication following liver
surgery, is mediated by the close contact of bacterial membrane vesicles, and influences the …

Clearance of apoptotic cells by neutrophils in inflammation and cancer

C Ramos, R Oehler - Cell Death Discovery, 2024 - nature.com
When a cell dies of apoptosis, it is eliminated either by neighbouring cells or by attracted
professional phagocytes. Although it was generally believed that neutrophils also have the …

[HTML][HTML] SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy

U Resch, H Hackl, D Pereyra, J Santol… - International Journal of …, 2024 - mdpi.com
Post-hepatectomy liver failure (PHLF) remains a significant risk for patients undergoing
partial hepatectomy (PHx). Reliable prognostic markers and treatments to enhance liver …

Fully Bioactive Nanodrugs: Stem Cell-Derived Exosomes Engineered with Biomacromolecules to Treat CCl4- and Extreme Hepatectomy-Induced Acute Liver Failure

M Sun, M Li, M Hu, Y Fan, Y Liu, J Sun, J Zhang - ACS nano, 2024 - ACS Publications
Acute liver failure (ALF) is a serious global disease characterized by rapid onset and high
mortality. Currently, the clinical treatment of ALF faces considerable hurdles due to limited …