Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Purpose Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely
studied for more than six decades. Here we review the importance of hypoxia to …

Macrophages orchestrate tissue homeostasis and immunity. In the tumor microenvironment
(TME), macrophage presence is largely associated with poor prognosis because of their …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Emerging evidence indicates that metabolism not only is a source of energy and
biomaterials for cell division but also acts as a driver of cancer cell plasticity and treatment …

Epigenetic phenomena play a central role in cell regulatory processes and are important
factors for understanding complex human disease. One of the best understood epigenetic …

β-adrenergic receptor (β-AR) signaling plays predominant roles in modulating energy
expenditure by triggering lipolysis and thermogenesis in adipose tissue, thereby conferring …

Goldfish enter a hypometabolic state to survive chronic hypoxia. We recently described
tissue-specific contributions of membrane lipid composition remodeling and mitochondrial …

DNA and RNA methylation dynamics have been linked to a variety of cellular processes
such as development, differentiation, and the maintenance of genome integrity. The correct …

The basal endosperm transfer layer (BETL) of the maize (Zea mays L.) kernel is composed
of transfer cells for nutrient transport to nourish the develo** kernel. To understand the …