Natural products for drug discovery in the 21st century: innovations for novel drug discovery
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …
pathological conditions have been treated using plant-derived medicines. These medicines …
[HTML][HTML] The role of natural products as sources of therapeutic agents for innovative drug discovery
K Dzobo - Comprehensive pharmacology, 2022 - ncbi.nlm.nih.gov
Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …
treatment strategies, placing natural products at the center of efforts to obtain new therapies …
Ginsenoside Rb1 as an anti-diabetic agent and its underlying mechanism analysis
P Zhou, W **e, S He, Y Sun, X Meng, G Sun, X Sun - Cells, 2019 - mdpi.com
Panax ginseng and Panax notoginseng, two well-known medical plants with economic
value, have a long history of use for managing various diseases in Asian countries …
value, have a long history of use for managing various diseases in Asian countries …
Current trends in toxicity assessment of herbal medicines: A narrative review
Even in modern times, the popularity level of medicinal plants and herbal medicines in
therapy is still high. The World Health Organization estimates that 80% of the population in …
therapy is still high. The World Health Organization estimates that 80% of the population in …
[HTML][HTML] TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway …
W Tang, M Dong, F Teng, J Cui, X Zhu, W Wang… - Biomedicine & …, 2021 - Elsevier
Highlights•Acupuncture was effective in attenuation of AHR, mucus secretion and airway
inflammation in OVA-induced mouse asthma model.•Suppression of SLC3A2 and ATP1A3 …
inflammation in OVA-induced mouse asthma model.•Suppression of SLC3A2 and ATP1A3 …
Computational analyses of mechanism of action (MoA): data, methods and integration
The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the
drug discovery process, but it is important in order to rationalise phenotypic findings and to …
drug discovery process, but it is important in order to rationalise phenotypic findings and to …
Bacteriocins: perspective for the development of novel anticancer drugs
Antimicrobial peptides (AMPs) from prokaryotic source also known as bacteriocins are
ribosomally synthesized by bacteria belonging to different eubacterial taxonomic branches …
ribosomally synthesized by bacteria belonging to different eubacterial taxonomic branches …
From **aoke to diabetes mellitus: a review of the research progress in traditional Chinese medicine for diabetes mellitus treatment
X Meng, X Liu, J Tan, Q Sheng, D Zhang, B Li… - Chinese medicine, 2023 - Springer
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia
resulting from insulin secretion defects or insulin resistance. The global incidence of DM has …
resulting from insulin secretion defects or insulin resistance. The global incidence of DM has …
Network pharmacology to unveil the biological basis of health-strengthening herbal medicine in cancer treatment
Health-strengthening (Fu-Zheng) herbs is a representative type of traditional Chinese
medicine (TCM) widely used for cancer treatment in China, which is in contrast to pathogen …
medicine (TCM) widely used for cancer treatment in China, which is in contrast to pathogen …
Lariciresinol induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway
ZJ Ma, L Lu, JJ Yang, XX Wang, G Su, Z Wang… - European Journal of …, 2018 - Elsevier
Lariciresinol (LA) is one of the main active ingredients in many traditional medicinal plants
such as Patrinia, and has the role of anti-liver cancer. However, the precise mechanisms are …
such as Patrinia, and has the role of anti-liver cancer. However, the precise mechanisms are …