Quercetin and metabolic syndrome: A review
Metabolic syndrome (MetS) is a complex of diseases that lead to mortality due to the
development of cardiovascular problems. Quercetin, as an important flavonoid, has various …
development of cardiovascular problems. Quercetin, as an important flavonoid, has various …
SIRT1 activation by natural phytochemicals: an overview
Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases
The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …
[HTML][HTML] Diabetes mellitus: The epidemic of the century
The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …
SIRT1 and other sirtuins in metabolism
HC Chang, L Guarente - Trends in Endocrinology & Metabolism, 2014 - cell.com
Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their
function is intrinsically linked to cellular metabolism. Over the past two decades …
function is intrinsically linked to cellular metabolism. Over the past two decades …
[HTML][HTML] The diagnostic approach to monogenic very early onset inflammatory bowel disease
HH Uhlig, T Schwerd, S Koletzko, N Shah… - Gastroenterology, 2014 - Elsevier
Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
Abstract Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide
(NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them …
(NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them …
Targeting inflammation in the treatment of type 2 diabetes: time to start
MY Donath - Nature reviews Drug discovery, 2014 - nature.com
The role of inflammation in the pathogenesis of type 2 diabetes and associated
complications is now well established. Several conditions that are driven by inflammatory …
complications is now well established. Several conditions that are driven by inflammatory …
[HTML][HTML] Type 2 diabetes mellitus: from a metabolic disorder to an inflammatory condition
I Hameed, SR Masoodi, SA Mir, M Nabi… - World journal of …, 2015 - ncbi.nlm.nih.gov
Diabetes mellitus is increasing at an alarming rate and has become a global challenge.
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …
Anti-inflammatory therapies for cardiovascular disease
PM Ridker, TF Lüscher - European heart journal, 2014 - academic.oup.com
Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in
the arterial wall. Rather, the initiation and progression of atherosclerotic lesions is currently …
the arterial wall. Rather, the initiation and progression of atherosclerotic lesions is currently …