The intricate balance of immune reactions towards invading pathogens and immune
tolerance towards self is pivotal in preventing autoimmune diseases, with the thymus playing …

The extent of central T cell tolerance is determined by the diversity of self-antigens that
develo** thymocytes 'see'on thymic antigen-presenting cells (APCs). Here, focusing on …

In the vertebrate immune system, thymus stromal microenvironments support the generation
of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance …

The establishment of an adaptive immune system is critical for protecting our bodies from
neoplastic cancers and invading pathogens such as viruses and bacteria. As a primary …

Abstract The Autoimmune Regulator, AIRE, acts as a transcriptional regulator in the thymus,
facilitating ectopic expression of thousands of genes important for the process of negative T …